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5), with the exception of Vuse Alto® Menthol zinc (867–4,580 ng/10 puffs). Tin and lead concentrations were low in our previous ENDS results as well as in most pod liquid samples used for this study. One exception for tin was observed in myblu™ Tobacco Chill liquid where the concentration was greater than the other pod liquid concentrations. In aerosol, there were detectable tin and lead values among the pods. The highest tin aerosol concentration ranged from 81.2 to 127 ng/10 puffs, and the highest aerosol lead concentration ranged from 96.5 to 463 ng/10 puffs.

JUUL and E

This can lead to lung damage like scarring and narrowing of the tubes that bring air in and out of your lungs. Researchers don’t yet know all the effects vaping can have on your body. We showedthat JUUL exposure affected the expression of pro-inflammatory cytokines in colonic tissue under homeostatic conditions.

Fibrosis analysis

We do not mean to overstate our findings and have revised the manuscript to avoid that. The authors observed neuroinflammation in brain regions responsible for behavior modification, drug reward and formation of anxious or depressive behaviors after exposure to JUUL. It would help demonstrate the pathogenic role of the neuroinflammation by testing animal behaviors. It is unclear why the authors do not present their gene expression data in the form of a heatmap instead of 24 small individual graphs (e.g., Figures 3 and 6).

Can You Minimize Vaping Side Effects?

The lead concentrations in most ENDS aerosols, however, were much lower than in mainstream smoke, with the exception of the Vuse Alto® Menthol aerosols. The typical lower delivery of lead in most ENDS likely is due to the lower temperatures in ENDS heating coils compared to a burning cigarette coal temperature during inhalation. บุหรี่ไฟฟ้ารุ่นไหนดี agree with the reviewer, that confirmation with protein levels would yield the strongest data possible. In the original manuscript we did include protein-based quantification data for the brain and lung. However, we did not have enough tissue to conduct protein-based studies on colon tissue. Although we were unable to include protein based quantification for all organs, we do feel that our original intention of demonstrating broad reaching effects of e-cigarette aerosols across the body was still achieved.

In this study we investigated the impact of inhalation of aerosols produced from pod-based, flavored e-cigarettes aerosols three times daily for 3 months on inflammatory markers in the brain, lung, heart, and colon. JUUL aerosol exposure induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens in the central nervous system. Inflammatory gene expression increased in the colon, while gene expression was more broadly altered by e-cigarette aerosol inhalation in the lung. Cardiopulmonary inflammatory responses to acute lung injury with lipopolysaccharide were exacerbated in the heart.

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